Studies on Isonicotino-hydrazide Derivatives. V
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چکیده
منابع مشابه
Structure Activity Relationship of Brevenal Hydrazide Derivatives
Brevenal is a ladder frame polyether produced by the dinoflagellate Karenia brevis. This organism is also responsible for the production of the neurotoxic compounds known as brevetoxins. Ingestion or inhalation of the brevetoxins leads to adverse effects such as gastrointestinal maladies and bronchoconstriction. Brevenal shows antagonistic behavior to the brevetoxins and shows beneficial attrib...
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The antituberculous activity of isoniazid used alone or in combination with streptomycin or para-aminosalicylic acid (PAS) has been established.’ One of the most favorable properties of isoniazid is the low incidence of significant toxicity resulting from its use when doses of 3 to 5 mg. per kilogram per day are administered. Some of the reactions reported include toxic psychosis, convulsions, ...
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The reaction of cyclopentanone with cyanoacetylhydrazine gave 2-cyano-2-cyclopentylideneacetohydrazide (1). Treatment of compound 1 with elemental sulphur in the presence of triethylamine afforded 2-amino-5,6-dihydro- -4H-cyclopenta[b]thiophene-3-carbohydrazide (2), which in-turn formed the corresponding intermediate diazonium salt. The latter was coupled with either ethyl cyanoacetate or ethyl...
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The uses of non-steroidal anti-inflammatory drugs (NSAIDs) are limited by a variety of side effects. So research on preparing new analgesic agents is important. According to some reports about the analgesic activity of hydrazide and hydrazine derivatives a new series of these compounds were synthesized in order to obtain new analgesic compounds. The final compounds 10a-10e and 15a-15d were pre...
متن کاملSynthesis and analgesic activity of novel Hydrazide and Hydrazine derivatives
The uses of non-steroidal anti-inflammatory drugs (NSAIDs) are limited by a variety of side effects. So research on preparing new analgesic agents is important. According to some reports about the analgesic activity of hydrazide and hydrazine derivatives a new series of these compounds were synthesized in order to obtain new analgesic compounds. The final compounds 10a-10e and 15a-15d were pre...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1960
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.80.2_214